Searchable abstracts of presentations at key conferences in endocrinology

ea0073oc9.4 | Oral Communications 9: Endocrine-Related Cancer | ECE2021

Splicing machinery landscape is dysregulated in chronic liver disease: central role of EIF4A3 in hepatocarcinogenesis.

López-Cánovas Juan Luis , Hermán-Sánchez Natalia , Moreno-Montilla María T , del Rio-Moreno Mercedes , Sánchez-Frias Marina E. , Amado Víctor , Ciria Rubén , Briceño Javier , de la Mata Manuel , Castaño Justo P. , Rodriguez-Perálvarez Manuel , Luque Raul M , Gahete Ortiz Manuel

Endocrine-metabolic alterations such as obesity and metabolic syndrome are closely linked to the development of chronic liver diseases, from metabolic-associated fatty liver (MAFLD) to non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). An emerging hallmark of endocrine-metabolic and hepatic diseases is the appearance or altered expression of pathological splicing variants (SVs). In fact, the components of the cellular machinery involved in the splicing pr...